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Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Identifieur interne : 002469 ( Main/Exploration ); précédent : 002468; suivant : 002470

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Auteurs : SHIMING LI [États-Unis] ; Ted Lambros [États-Unis] ; ZHENYU WANG [États-Unis] ; Robert Goodnow [États-Unis] ; Chi-Tang Ho [États-Unis]

Source :

Journal of chromatography. B [ 1570-0232 ] ; 2007.

RBID : Pascal:07-0095133

Descripteurs français

Pascal (Inist)
- Isolement, Pelure, Extrait, Chromatographie SFC, Citrus sinensis, Caractérisation, Orange douce.

English descriptors

KwdEn :
- Characterization, Citrus sinensis, Extract, Isolation, Peel, Supercritical fluid chromatography, Sweet orange.

Abstract

Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.</div>
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Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri